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Cyclin D2 Polyclonal antibody

Cyclin D2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse and More (3)

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 10934-1-AP

Synonyms

CCND2, cyclin D, cyclin D2, G1/S-specific cyclin-D2



Tested Applications

Positive WB detected inCaco-2 cells, MCF-7 cells, NIH/3T3 cells, U2OS cells, HEK-293 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
Sample-dependent, check data in validation data gallery

Product Information

10934-1-AP targets Cyclin D2 in WB, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivity bovine, goat, human, mouse, pig
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Cyclin D2 fusion protein Ag1377
Full Name cyclin D2
Calculated molecular weight 32 kDa
Observed molecular weight 34 kDa
GenBank accession numberBC010958
Gene symbol CCND2
Gene ID (NCBI) 894
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

CCND2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. CCND2 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. High level expression of CCND2 was observed in ovarian and testicular tumors.

Protocols

Product Specific Protocols
WB protocol for Cyclin D2 antibody 10934-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Cancer Manag Res

ADAR1 may be involved in the proliferation of acute myeloid leukemia cells via regulation of the Wnt pathway.

Authors - Han Xiao
humanWB

Cancer Biol Med

Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis.

Authors - Caijun Zha
humanWB

Cell Death Dis

GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia.

Authors - Cheng Zhou
bovineWB

Adipocyte

MiR-33a plays an crucial role in the proliferation of bovine preadipocytes.

Authors - Wenzhen Zhang
goatWB

Domest Anim Endocrinol

Effects of chronic dexamethasone exposure on bile acid metabolism and cecal epithelia function in goats.

Authors - C Hua
humanWB

Mol Med Rep

PMID: 31432162

Authors - Ning Xie