CCNL1 Polyclonal antibody, PBS Only

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• CCNL1 Polyclonal antibody, PBS Only (13138-1-PBS)

• 

  WB analysis using 13138-1-AP (same clone as 13138-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 13138-1-AP (CCNL1 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13138-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 13138-1-AP (same clone as 13138-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 13138-1-AP (CCNL1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13138-1-PBS in a different storage buffer formulation.

CCNL1 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 13138-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

ania 6a, BM 001, BM-001, Cyclin L, cyclin L1

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Product Information

13138-1-PBS targets CCNL1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag3731

  Product name: Recombinant human CCNL1 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 227-526 aa of BC007081

  Sequence: YMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKAKGLNPDGTPALSTLGGFSPASKPSSPREVKAEEKSPISINVKTVKKEPEDRQQASKSPYNGVRKDSKRSRNSRSASRSRSRTRSRSRSHTPRRHYNNRRSRSGTYSSRSRSRSRSHSESPRRHHNHGSPHLKAKHTRDDLKSSNRHGHKRKKSRSRSQSKSRDHSDAAKKHRHERGHHRDRRERSRSFERSHKSKHHGGSRSGHGRHRR

• Full Name: cyclin L1
• Calculated Molecular Weight: 526 aa, 60 kDa
• Observed Molecular Weight: 46 kDa
• GenBank Accession Number: BC007081
• Gene Symbol: CCNL1
• Gene ID (NCBI): 57018
• RRID: AB_10640299
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9UK58
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CCNL1, also named as Cyclin-L1, contains a RS region and belongs to the cyclin family. CCNL1 localizes in the nucleus speckle and is Overexpressed in primary tumors of head and neck squamous cell carcinomas (HNSCC). CCNL1 as transcriptional regulator participates in regulating the pre-mRNA splicing process. It is seems to be involved in the regulation of RNA polymerase II (pol II). CCNL1 functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. It may be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). The calculated molecular weight of CCNL1 is about 55-60 kDa, but we detected a 40-50 kDa isoform by western blotting.