Cyclin T1 Polyclonal antibody
Cyclin T1 Polyclonal Antibody for IF, WB, ELISA
Host / Isotype
Rabbit / IgG
Cat no : 20992-1-AP
|Positive WB detected in||K-562 cells, A431 cells, Y79 cells, Jurkat cells, HeLa cells|
|Positive IF detected in||MCF-7 cells|
|Western Blot (WB)||WB : 1:200-1:1000|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
20992-1-AP targets Cyclin T1 in WB, IF applications and shows reactivity with human samples.
|Host / Isotype||Rabbit / IgG|
|Full Name||cyclin T1|
|Calculated molecular weight||81 kDa|
|Observed molecular weight||87 kDa|
|GenBank accession number||NM_001240|
|Gene ID (NCBI)||904|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
CCNT1, also named as CycT1, belongs to the cyclin family and Cyclin C subfamily. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex which also called positive transcription elongation factor B (P-TEFb). In case of HIV or SIV infections, CCNT1 binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). CCNT1 serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. The antibody is specific to CCNT1.
|Product Specific Protocols|
|WB protocol for Cyclin T1 antibody 20992-1-AP||Download protocol|
|IF protocol for Cyclin T1 antibody 20992-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Menin enhances c-Myc-mediated transcription to promote cancer progression.
Nucleic Acids Res
HMGA1 recruits CTIP2-repressed P-TEFb to the HIV-1 and cellular target promoters.