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Product Information
98745-1-PBS targets CCR4 in FC applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
unknow Predict reactive species |
| Full Name | chemokine (C-C motif) receptor 4 |
| Gene Symbol | CCR4 |
| Gene ID (NCBI) | 1233 |
| RRID | AB_3746312 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P51679 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
CC chemokine receptor 4 (CCR4) is important for regulating immune balance and is known to be expressed selectively on Th2 cells and Treg cells. Expression of CCR4 by tumor cells is associated with skin involvement, but CCR4 also has an important role in normal and tumor immunity (PMID: 16952304). CCR4+ adult T-cell leukemia/lymphoma is an example of the former phenomenon, and Hodgkin lymphoma of the latter, for which an almost identical immunopathogenesis has been reported in many types of cancer (PMID: 21044233, 12485447).
