CCR6 Monoclonal antibody
CCR6 Monoclonal Antibody for IF, IHC, ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
Human
Applications
IHC, IF
Conjugate
Unconjugated
CloneNo.
1C11A9
Cat no : 66801-1-Ig
Synonyms
Validation Data Gallery
Tested Applications
Positive IHC detected in | human tonsillitis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
Positive IF detected in | human tonsillitis tissue |
Recommended dilution
Application | Dilution |
---|---|
Immunohistochemistry (IHC) | IHC : 1:250-1:1000 |
Immunofluorescence (IF) | IF : 1:400-1:1600 |
Sample-dependent, check data in validation data gallery |
Product Information
66801-1-Ig targets CCR6 in IHC, IF applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | CCR6 fusion protein Ag24195 |
Full Name | chemokine (C-C motif) receptor 6 |
Calculated molecular weight | 42 kDa |
GenBank accession number | BC037960 |
Gene symbol | CCR6 |
Gene ID (NCBI) | 1235 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
CCR6, the gene encoding chemokine (C-C motif) receptor 6, that was a specific marker for Th17 cells, distinguishing them from other helper T-cells. Although CCR6 also expressed in IL-17-producing γδ T cells as well as in subsets of B cells and dendritic cells (PMID: 19830744 ). CCR6 polymorphism was associated with rheumatoid arthritis susceptibility (PMID: 20453841). CD196 is involved in host defense and inflammation at epithelial sites and in IL-17-driven autoimmunity in human diseases.
Protocols
Product Specific Protocols | |
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IHC protocol for CCR6 antibody 66801-1-Ig | Download protocol |
IF protocol for CCR6 antibody 66801-1-Ig | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |