CoraLite®594-conjugated CCR6 Monoclonal antibody

CCR6 Monoclonal Antibody for IF

Host / Isotype

Mouse / IgG2a

Reactivity

Human

Applications

IF

Conjugate

CoraLite®594 Fluorescent Dye

CloneNo.

1C11A9

Cat no : CL594-66801

Synonyms

BN 1, C C chemokine receptor type 6, C C CKR 6, CC CKR 6, CCR 6, CCR6, CD196, Chemokine receptor like 3, CKR L3, CKR6, CKRL3, CMKBR6, DCR2, DRY 6, DRY6, G protein coupled receptor 29, GPR CY4, GPR29, GPRCY4, LARC receptor, STRL22



Tested Applications

Positive IF detected inhuman tonsillitis tissue
For other applications, we recommend the unconjugated version of this antibody, 66801-1-Ig

Recommended dilution

ApplicationDilution
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

CL594-66801 targets CCR6 in IF applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen CCR6 fusion protein Ag24195
Full Name chemokine (C-C motif) receptor 6
Calculated molecular weight 42 kDa
GenBank accession numberBC037960
Gene symbol CCR6
Gene ID (NCBI) 1235
Conjugate CoraLite®594 Fluorescent Dye
Excitation/Emission maxima wavelengths593 nm / 614 nm
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.

Background Information

CCR6, the gene encoding chemokine (C-C motif) receptor 6, that was a specific marker for Th17 cells, distinguishing them from other helper T-cells. Although CCR6 also expressed in IL-17-producing γδ T cells as well as in subsets of B cells and dendritic cells (PMID: 19830744 ). CCR6 polymorphism was associated with rheumatoid arthritis susceptibility (PMID: 20453841). CD196 is involved in host defense and inflammation at epithelial sites and in IL-17-driven autoimmunity in human diseases.

Protocols

Product Specific Protocols
IF protocol for CL594 CCR6 antibody CL594-66801Download protocol
Standard Protocols
Click here to view our Standard Protocols