Anti-Human CD117/c-Kit Rabbit Recombinant Antibody, PBS Only

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  FC experiment of TF-1 using 98377-1-RR (same clone as 98377-1-PBS)

  1x10^6 TF-1 cells were surface stained with 0.25 ug Anti-Human C-Kit Rabbit RecAb (98377-1-RR, Clone:241313C5) and PE-Conjugated Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue). Cells were not fixed. This data was developed using the same antibody clone with 98377-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human blood cells using 98377-1-RR (same clone as 98377-1-PBS)

  1x10^6 human blood cells were surface stained with 0.25 ug Anti-Human C-Kit Rabbit RecAb (98377-1-RR, Clone:241313C5) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human CD34. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98377-1-PBS in a different storage buffer formulation.

CD117/c-Kit Uni-rAb^TM Recombinant Antibody for FC

Cat No. 98377-1-PBS

Clone No.241313C5

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

CD117, KIT, C Kit, c-Kit, EC:2.7.10.1

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Product Information

98377-1-PBS targets CD117/c-Kit in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
• Calculated Molecular Weight: 976 aa, 110 kDa
• GenBank Accession Number: BC071593
• Gene Symbol: CD117
• Gene ID (NCBI): 3815
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: P10721
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CD117, also known as c-Kit and SCFR, is a transmembrane protein with tyrosine kinase activity encoded by the oncogene c-kit (PMID: 2448137). It is a member of the type III receptor tyrosine kinase family, which also includes CSF-1R, PDGFRβ, PDGFRα, and FLT3 (PMID: 29518044). CD117 is expressed on hematopoietic stem cells and progenitor cells, mast cells, and is also found in a wide range of non-haemopoietic cell types (including melanocytes, germ cells, astrocytes, renal tubules, breast glandular epithelial cells, sweat glands, and interstitial cells of Cajal) (PMID: 10582338; 23073628). CD117 plays an important role in early hemopoiesis. It is also involved in pigmentation, fertility, gut movement, and some aspects of the nervous system (PMID: 23073628).