CD11B/Integrin Alpha M Polyclonal antibody
CD11B/Integrin Alpha M Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, IHC, IF,ELISA
Conjugate
Unconjugated
Cat no : 20991-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| Sample-dependent, check data in validation data gallery | |
Published Applications
| WB | See 9 publications below |
| IHC | See 3 publications below |
| IF | See 2 publications below |
Product Information
20991-1-AP targets CD11B/Integrin Alpha M in WB, IHC, IF,ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide |
| Full Name | integrin, alpha M (complement component 3 receptor 3 subunit) |
| Calculated molecular weight | 93 kDa |
| Observed molecular weight | 110-170 kDa |
| GenBank accession number | NM_000632 |
| Gene symbol | ITGAM |
| Gene ID (NCBI) | 3684 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).
Protocols
| Product Specific Protocols | |
|---|---|
| IHC protocol for CD11B/Integrin Alpha M antibody 20991-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
EBioMedicine A GBM-like V-ATPase signature directs cell-cell tumor signaling and reprogramming via large oncosomes. | ||
J Cell Mol Med The pattern-recognition molecule mindin binds integrin Mac-1 to promote macrophage phagocytosis via Syk activation and NF-κB p65 translocation. | ||
Brain Res Bull Systemic administration of scAAV9-IGF1 extends survival in SOD1G93AALS mice via inhibiting p38 MAPK and the JNK-mediated apoptosis pathway. | ||
Brain Res Bull scAAV9-VEGF-165 inhibits neuroinflammatory response and invasion of macrophages into the peripheral nervous system of ALS transgenic mice. | ||
Neurosci Lett IGF1 affects macrophage invasion and activation and TNF-α production in the sciatic nerves of female SOD1G93A mice. | ||
Neurochem Res Intrathecal Delivery of ssAAV9-DAO Extends Survival in SOD1(G93A) ALS Mice. |
