Anti-Human CD155/PVR (SKII.4)

CD155/PVR Monoclonal Antibody for FC

Host / Isotype

Mouse / IgG1, kappa

Reactivity

Human

Applications

FC

Conjugate

Unconjugated

CloneNo.

SKII.4

Cat no : 65251-1-Ig

Synonyms

CD155, FLJ25946, HVED, Necl 5, NECL5, Nectin like protein 5, poliovirus receptor, PVR, PVS, TAGE4



Tested Applications

Positive FC detected inU937

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

65251-1-Ig targets CD155/PVR in FC applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG1, kappa
Class Monoclonal
Type Antibody
Immunogen SK-N-AS human neuroblastoma cells
Full Name poliovirus receptor
Calculated Molecular Weight 45 kDa
GenBank Accession NumberBC015542
Gene Symbol PVR
Gene ID (NCBI) 5817
Conjugate Unconjugated
Form Liquid
Purification MethodAffinity purification
Storage Buffer PBS with 0.09% sodium azide.
Storage ConditionsStore at 2-8°C. Stable for one year after shipment.

Background Information

CD155, also known as PVR, is a type I transmembrane glycoprotein in the immunoglobulin superfamily. It contains three extracellular immunoglobulin-like domains, D1-D3, of which D1 is recognized by the virus. Mature human CD155 consists of a 323 amino acid extracellular domain with one N-terminal V-type and two C2-type Ig-like domains, a 24 amino acid transmembrane segment, and a 50 amino acid cytoplasmic tail. CD155 is thought to play a role in adhesion by interaction with the ECM component vitronectin as well as a role in NK killing of tumor cells. CD155 binds to two receptors of NK cells, CD96 and CD226, and accumulates at cell-cell contact sites, leading to the formation of mature immune synapses between NK cells and target cells. CD155 serves as the entry receptor for poliovirus and thereby mediates human susceptibility to poliovirus infection.

Protocols

Product Specific Protocols
FC protocol for CD155/PVR antibody 65251-1-IgDownload protocol
Standard Protocols
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