Anti-Mouse CD18 (M18/2) Rat Recombinant Antibody, PBS Only

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• Anti-Mouse CD18 (M18/2) Rat Recombinant Antibody, PBS Only (65671-1-PBS)

CD18 Uni-rAb^® Recombinant Antibody for FC

Cat No. 65671-1-PBS Copied!

Clone No. M18/2

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Host / Isotype

Rat / IgG2a

Reactivity

mouse

Applications

FC

Synonyms

Itgb2, integrin beta 2, LAD, LCAMB, Lfa1

• 

  FC experiment of mouse thymocytes using 65671-1-TR (same clone as 65671-1-PBS)

  1x10^6 mouse thymocytes were surface stained with 0.5 ug Anti-Mouse CD18 (M18/2) Rat IgG2a RecAb (65671-1-TR, Clone:M18/2) or Rat IgG2a Isotype Control Recombinant Antibody (98427-1-TR, Clone: 250862A1), and FITC anti-Rat IgG2a antibody. Cells were not fixed. This data was developed using the same antibody clone with 65671-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  FC experiment of mouse thymocytes using 65671-1-TR (same clone as 65671-1-PBS)

  1x10^6 mouse thymocytes were surface stained with 0.5 ug Anti-Mouse CD18 (M18/2) Rat IgG2a RecAb (65671-1-TR, Clone:M18/2) (red) or Rat IgG2a Isotype Control Recombinant Antibody (98427-1-TR, Clone: 250862A1) (blue), and FITC anti-Rat IgG2a antibody. Cells were not fixed. This data was developed using the same antibody clone with 65671-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Product Information

65671-1-PBS targets CD18 in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rat / IgG2a
• Class: Recombinant
• Type: Antibody
• Immunogen:

  N/A

• Full Name: integrin beta 2
• GenBank Accession Number: BC145644
• Gene Symbol: CD18
• Gene ID (NCBI): 16414
• RRID: AB_3743289
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P11835
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CD18, also known as integrin beta-2, is a transmembrane protein that forms heterodimers with CD11a, CD11b, CD11c, CD11d (PMID: 1968349). CD11a/CD18 (LFA-1) is expressed by all leukocytes, while CD11b/CD18 (Mac-1) and CD11c/CD18 (p150,95) are normally restricted to expression on monocytes, macrophages, polymorphonuclear lymphocytes (PMNs), and natural killer cells (PMID: 1968349; 3109455; 10946284). CD18 plays an important role in mediating cell adhesion during immune response and defects of CD18 cause leukocyte adhesion deficiency (PMID: 3594570).