CoraLite® Plus 488 Anti-Human CD19 (4G7)
CD19 Monoclonal Antibody for FC
Host / Isotype
Mouse / IgG1, kappa
CoraLite® Plus 488 Fluorescent Dye
Cat no : CL488-65197
|Positive FC detected in
|This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 μl per 10^6 cells in a 100 µl suspension or 5 μl per 100 µl of whole blood.
|Sample-dependent, check data in validation data gallery
CL488-65197 targets CD19 in FC applications and shows reactivity with Human samples.
|Host / Isotype
|Mouse / IgG1, kappa
|Human chronic lymphocytic leukemia (CLL) cells
|Calculated molecular weight
|556 aa, 61 kDa
|GenBank accession number
|Gene ID (NCBI)
|CoraLite® Plus 488 Fluorescent Dye
|Excitation/Emission maxima wavelengths
|493 nm / 522 nm
|Protein G purification
|PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3.
|Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.
CD19 is a 95 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily (PMID: 2472450). It is expressed by B cells and follicular dendritic cells. CD19 is up-regulated at the step of B-lineage commitment during the differentiation of the hematopoietic stem cell, it remains on during subsequent stages of differentiation until finally down-regulated during terminal differentiation into plasma cells (PMID: 8528044). CD19 is involved in B cell development, activation and differentiation. It is the dominant component for the signaling complex on B cells that includes CD21 (CR2), CD81 (TAPA-1) and CD225 and acts as a critical co-receptor for BCR signal transduction (PMID: 23210908).