CD247 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 12837-2-AP

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Freight/Packing

Con: 45 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, human spleen tissue, mouse spleen tissue

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human tonsillitis tissue, human lymphoma tissue, human tonsillitis tissue

Positive FC detected in:
Jurkat cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CD247 molecule

Calculated molecular weight:
16 kDa

Observed molecular weight:
16 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CD247

Synonyms
CD247, CD247 molecule, CD3 ZETA, CD3H, CD3Q, CD3Z, T cell receptor T3 zeta chain, T3Z, TCRZ
Background

CD247, also known as CD3Z (T-cell surface glycoprotein CD3 zeta chain), belongs to the CD3Z/FCER1G family. CD3 is a complex of proteins that directly associates with the T cell receptor (TCR). The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. The TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. TCR-mediated peptide-MHC recognition is transmitted to the CD3 complex, leading to the intracellular signal transduction. CD3 is considered to be a pan-T cell marker for detection of normal and neoplastic T cells.


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