Product Information
65620-1-PBS targets CD25/IL-2RA in FC applications and shows reactivity with human, monkey, non-human primates samples.
| Tested Reactivity | human, monkey, non-human primates |
| Host / Isotype | Mouse / IgG2a |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
N/A Predict reactive species |
| Full Name | interleukin 2 receptor, alpha |
| Calculated Molecular Weight | 272 aa, 31 kDa |
| GenBank Accession Number | BC156627 |
| Gene Symbol | IL2RA |
| Gene ID (NCBI) | 3559 |
| RRID | AB_3670363 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P01589 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Proliferation of T lymphocytes is triggered by the interaction of IL-2 with its specific receptor following T lymphocyte activation. The receptor for IL-2 has three forms, generated by different combinations of three different proteins, the alpha chain (IL-2R alpha), the beta chain (IL-2R beta), and the gamma chain (IL-2R gamma) (PMID: 8476561). IL-2R alpha (also known as CD25) is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes. CD25 is also found on natural CD4+Foxp3+ Treg cells and a subset of human CD4+ memory T cells (PMID: 22585674).
