B7-H3 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 14453-1-AP

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Freight/Packing

Con: 28 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
PC-3 cells, HEK-293 cells, PC-3 cells

Positive IHC detected in:
human medulloblastoma tissue, human medulloblastoma tissue, human testis tissue

Positive FC detected in:
RAW 264.7 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CD276 molecule

Calculated molecular weight:
57 kDa

Observed molecular weight:
100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CD276

Synonyms
4Ig B7 H3, B7 homolog 3, B7-H3, CD276, CD276 antigen, CD276 molecule, Costimulatory molecule, UNQ309/PRO352
Background

B7-H3 (CD276) is a type I transmembrane protein expressed on many tissues and cell types. B7-H3 belongs to the B7 immunoregulatory family and participate in the regulation of T-cell-mediated immune response probably by functioning as both a T cell costimulator and coinhibitor (PMID: 20696859). Overexpressed on a wide range of human solid cancers, B7-H3 has been implicated in cancer progression and metastasis and becomes an attractive target for cancer immunotherapy (PMID: 27208063).


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