|Positive FC detected in||mouse splenocytes|
|This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.|
|Sample-dependent, check data in validation data gallery|
FITC-65058 targets CD31 in FC applications and shows reactivity with Mouse samples.
|Host / Isotype||Rat / IgG2a|
|Immunogen||C3H/HeJ mouse hematopoietic progenitor cell line 32D|
|Full Name||platelet/endothelial cell adhesion molecule 1|
|GenBank accession number||BC008519|
|Gene ID (NCBI)||18613|
|Conjugate||FITC Fluorescent Dye|
|Excitation/Emission maxima wavelengths||494 nm/520 nm|
|Purification Method||Affinity purification|
|Storage Buffer||PBS with 0.1% sodium azide.|
|Storage Conditions||Store at 2-8°C. Avoid exposure to light.|
Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein that is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. PECAM-1 is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, PECAM-1 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489).