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CDC42BPB Polyclonal antibody, PBS Only (31526-1-PBS)

CDC42BPB Polyclonal antibody, PBS Only

Name: CDC42BPB Polyclonal antibody, PBS Only,
Brand: Proteintech

CDC42BPB Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 31526-1-PBS

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Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Synonyms

DMPK like beta, KIAA1124, MRCK beta, MRCKB

Formulation: PBS Only

PBS, Azide, Glycerol

Conjugate: Unconjugated

Size/Concentration:

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Filter: AllWBIHC

WB analysis using 31526-1-AP (same clone as 31526-1-PBS)
Various lysates were subjected to SDS PAGE followed by western blot with 31526-1-AP (CDC42BPB antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31526-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
IHC staining of mouse cerebellum using 31526-1-AP (same clone as 31526-1-PBS)
Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 31526-1-AP (CDC42BPB antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31526-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
IHC staining of rat lung using 31526-1-AP (same clone as 31526-1-PBS)
Immunohistochemical analysis of paraffin-embedded rat lung tissue slide using 31526-1-AP (CDC42BPB antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31526-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
IHC staining of rat ovary using 31526-1-AP (same clone as 31526-1-PBS)
Immunohistochemical analysis of paraffin-embedded rat ovary tissue slide using 31526-1-AP (CDC42BPB antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31526-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
IHC staining of rat ovary using 31526-1-AP (same clone as 31526-1-PBS)
Immunohistochemical analysis of paraffin-embedded rat ovary tissue slide using 31526-1-AP (CDC42BPB antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 31526-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications
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Product Information

31526-1-PBS targets CDC42BPB in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity	human, mouse, rat
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	CatNo: Ag35745 Product name: Recombinant human CDC42BPB protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1530-1711 aa of NM_006035.3 Sequence: SGAVLNVPDTSDNSKKQMLRTRSKRRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSAVPPSQEERPGPAPTNLARQPPSRNKPYISWPSSGGSEPSVTVPLRSMSDPDQDFDKEPDSDSTKHSTPSNSSNPSGPPSPNSPHRSQLPLEGLEQPACDT Predict reactive species
Full Name	CDC42 binding protein kinase beta (DMPK-like)
Calculated Molecular Weight	194 kDa
Observed Molecular Weight	194 kDa
GenBank Accession Number	NM_006035.3
Gene Symbol	CDC42BPB
Gene ID (NCBI)	9578
RRID	AB_3670021
Conjugate	Unconjugated
Form	Liquid
Purification Method	Antigen affinity Purification
UNIPROT ID	Q9Y5S2
Storage Buffer	PBS only, pH 7.3.
Storage Conditions	Store at -80°C.

Background Information

CDC42BPB is a serine/threonine protein kinase and codes for MRCKβ (myotonic dystrophy-related Cdc42-binding kinase beta), a regulator of cell cytoskeletal reorganization and cell migration. CDC42BPB shows expression in the granule cell layer of the lateral adult cerebellum, which has been associated with cognitive functions, and has recently been associated with neurodevelopmental disorders including ASD (autism spectrum disorder). (PMID: 35942939)