Anti-Human CEACAM3/6 (CD66c/d) Rabbit Recombinant Antibody, PBS Only

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  FC experiment of human peripheral blood leukocytes using 98169-1-RR (same clone as 98169-1-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CEACAM3/6 (CD66c/d) Rabbit Recombinant Antibody (98169-1-RR, Clone: 241254D1) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98169-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98169-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98169-1-RR against Human CEACAM3/6 (CD66c/d) were performed. The affinity constant is 2.19 nM.

CEACAM3/6 (CD66c/d) Uni-rAb^® Recombinant Antibody for FC

Cat No. 98169-1-PBS

Clone No.241254D1

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

CEACAM3, CGM1, CD66D, Carcinoembryonic antigen-related cell adhesion molecule 3, Carcinoembryonic antigen CGM1

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Product Information

98169-1-PBS targets CEACAM3/6 (CD66c/d) in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Recombinant protein

• Full Name: carcinoembryonic antigen-related cell adhesion molecule 3
• Calculated Molecular Weight: 252 aa, 27 kDa
• GenBank Accession Number: BC106728
• Gene Symbol: CEACAM3
• Gene ID (NCBI): 1084
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: P40198
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to the immunoglobulin superfamily of cell adhesion molecules. CEACAMs play major roles in cell-cell and cell-ECM adhesion and have been implicated in controlling cell proliferation, angiogenesis, and tissue remodeling (PMID: 23021083). CEACAM3, also named as CD66d and CGM1, is exclusively expressed on granulocytes and acts as the major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms (PMID: 18606569). CEACAM6, also known as CD66c, is normally expressed on the surface of myeloid and epithelial surfaces and upregulated preferentially at the apical/luminal membranes of many tumors (PMID: 27595061; 35082925). This antibody is raised against 35-155 aa of human CEACAM3/CD66d and can cross-react with CEACAM6/CD66c.