Product Information
32923-1-PBS targets CHD1L in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag38526 Product name: Recombinant human CHD1L protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 704-897 aa of NM_004284.5 Sequence: SAELDYQDPDATSLKYVSGDVTHPQAGAEDALIVHCVDDSGHWGRGGLFTALEKRSAEPRKIYELAGKMKDLSLGGVLLFPVDDKESRNKGQDLLALIVAQHRDRSNVLSGIKMAALEEGLKKIFLAAKKKKASVHLPRIGHATKGFNWYGTERLIRKHLAARGIPTYIYYFPRSKSAVLHSQSSSSSSRQLVP* Predict reactive species |
| Full Name | chromodomain helicase DNA binding protein 1-like |
| Calculated Molecular Weight | 101kDa，897aa |
| Observed Molecular Weight | 101 kDa |
| GenBank Accession Number | NM_004284.5 |
| Gene Symbol | CHD1L |
| Gene ID (NCBI) | 9557 |
| RRID | AB_3742789 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q86WJ1 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
CHD1L (Chromodomain Helicase DNA Binding Protein 1-Like), also known as ALC1 (Amplified in Liver Cancer 1), encodes a multifunctional protein involved in various cellular processes such as chromatin remodeling, cell differentiation, and development. CHD1L acts as an ATP-dependent chromatin remodeling enzyme with an ATPase catalytic domain activated by double-stranded DNA. It interacts with PARP1 (poly-ADP-ribose polymerase 1) to promote chromatin relaxation at DNA damage sites, facilitating DNA repair. Overexpression of CHD1L leads to dysregulation of downstream targets in various cancers.
