CHTF18 Polyclonal antibody, PBS Only

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• CHTF18 Polyclonal antibody, PBS Only (13030-1-PBS)

CHTF18 Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 13030-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Synonyms

C16orf41, CTF18, hCTF18, RUVBL

• 

  WB analysis using 13030-1-AP (same clone as 13030-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 13030-1-AP (CHTF18 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13030-1-PBS in a different storage buffer formulation.

• 

  WB analysis of Y79 using 13030-1-AP (same clone as 13030-1-PBS)

  Y79 cells were subjected to SDS PAGE followed by western blot with 13030-1-AP (CHTF18 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13030-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human medulloblastoma using 13030-1-AP (same clone as 13030-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human medulloblastoma using 13030-1-AP (CHTF18 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 13030-1-PBS in a different storage buffer formulation.

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Product Information

13030-1-PBS targets CHTF18 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag3672

  Product name: Recombinant human CHTF18 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 657-975 aa of BC018184

  Sequence: LRLRLRDSSLGAVCVALDWLAFDDLLAGAAHHSQSFQLLRYPPFLPVAFHVLFASSHTPRITFPSSQQEAQNRMSQMRNLIQTLVSGIAPATRSRATPQALLLDALCLLLDILAPKLRPVSTQLYSTREKQQLASLVGTMLAYSLTYRQERTPDGQYIYRLEPNVEELCRFPELPARKPLTYQTKQLIAREIEVEKMRRAEASARVENSPQVDGSPPGLEGLLGGIGEKGVHRPAPRNHEQRLEHIMRRAAREEQPEKDFFGRVVVRSTAVPSAGDTAPEQDSVERRMGTAVGRSEVWFRFNEGVSNAVRRSLYIRDLL

• Full Name: CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
• Calculated Molecular Weight: 1184 aa, 129 kDa
• Observed Molecular Weight: 110 kDa
• GenBank Accession Number: BC018184
• Gene Symbol: CHTF18
• Gene ID (NCBI): 63922
• RRID: AB_2260469
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q8WVB6
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CHTF18 (Chromosome Transmission Fidelity Factor 18), also known as CTF18, operates primarily as a scaffolding and loading factor during the S phase of the cell cycle. CHTF18 is a core component of an alternative Replication Factor C (RFC) complex, which is essential for DNA replication, sister chromatid cohesion, and the DNA damage response. It is predominantly localized within the nucleus (nucleoplasm), anchoring directly to chromatin during DNA replication.