CLEC10A/CD301 Recombinant monoclonal antibody

• 

  WB analysis using 84748-1-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 84748-1-RR (CLEC10A antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours.

CLEC10A/CD301 Uni-rAb^® Recombinant Antibody for WB, ELISA

Cat No. 84748-1-RR

Clone No.241857C3

Publications(1)

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Synonyms

CLEC10A, C-type lectin domain family 10 member A, CLECSF14, CLECSF13, CD301

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Tested Applications

• Positive WB detected in: K-562 cells, Raji cells, mouse testis tissue

Recommended dilution

• Western Blot (WB): WB : 1:2000-1:16000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• WB: See 1 publications below

Product Information

84748-1-RR targets CLEC10A/CD301 in WB, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Recombinant protein

• Full Name: C-type lectin domain family 10, member A
• Calculated Molecular Weight: 316 aa, 35 kDa
• Observed Molecular Weight: 35 kDa
• GenBank Accession Number: BC039011
• Gene Symbol: CLEC10A
• Gene ID (NCBI): 10462
• RRID: AB_3672131
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q8IUN9
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

C-type lectin domain family 10 member A (CLEC10A), also known as CD301, macrophage galactose-type C-type lectin (MGL), DC-asialoglyco protein receptor (DC-ASGP-R) or human macrophage lectin (HML), is a type II transmembrane glycoprotein having a calcium-dependent carbohydrate recognition domain (PMID: 8598452; 11919201; 11698450). CLEC10A is expressed exclusively by myeloid professional antigen-presenting cells such as immature dendritic cells (DCs) and alternatively activated macrophages (PMID: 16998493). CLEC10A is a marker for human CD1c+ DCs (cDC2) (PMID: 29755453). It functions as an endocytic receptor for glycosylated antigens (PMID: 11919201).

Publications

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
human	WB	Free Radic Biol Med; 8-Oxoguanine Modifications in Peripheral Leukocyte microRNAs Promote Age-related Inflammation by Remodeling Gene Regulatory Networks; Authors - Ming-Ming Han