Anti-Mouse CLEC12A/CD371 Rabbit Recombinant Antibody, PBS Only

• 

  FC experiment of mouse splenocytes using 98357-1-RR (same clone as 98357-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse CLEC12A/CD371 Rabbit RecAb (98357-1-RR, Clone: 242620B12) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 405 Anti-Mouse CD11c (N418) Mouse IgG2a Recombinant Antibody (CL405-65602, Clone: N418) and APC Anti-Mouse CD8a (53-6.7) (APC-65069, Clone: 53-6.7). CD8+ cells were gated. Cells were not fixed. This data was developed using the same antibody clone with 98357-1-PBS in a different storage buffer formulation.

CLEC12A/CD371 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98357-1-PBS

Clone No.242620B12

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Synonyms

CD371, Clec12a, CLL-1, C-type lectin domain family 12 member A, C-type lectin-like molecule 1

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Product Information

98357-1-PBS targets CLEC12A/CD371 in FC applications and shows reactivity with mouse samples.

• Tested Reactivity: mouse
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg2726

  Product name: Recombinant Mouse CLEC12A protein (rFc Tag) (HPLC verified)

  Source: mammalian cells-derived, V37

  Tag: C-rFc

  Domain: 65-267 aa of /

  Sequence: YTTLATEMIKSNQLQRAKEELQENVFLQLKHNLNSSKKIKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMACSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTDDIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR

• Full Name: C-type lectin domain family 12, member a
• Calculated Molecular Weight: 31 kDa
• GenBank Accession Number: /
• Gene Symbol: Clec12a
• Gene ID (NCBI): 232413
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q504P2
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CLEC12A, also known as CD371, MICL, DCAL-2 or CLL-1, is a type II transmembrane glycoprotein and a member of the C-type lectin superfamily (PMID: 30401586). This protein, which contains a single C-type lectin-like domain and a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), is related to LOX-1 and Dectin-1 and is variably spliced and highly N-glycosylated (PMID: 14739280). Its ITIM sequence recruits the tyrosine phosphatases SHP-1 and SHP-2 to negatively regulate Syk signaling.