CLEC9A Polyclonal antibody, PBS Only

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• CLEC9A Polyclonal antibody, PBS Only (55451-1-PBS)

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  IHC staining of human tonsillitis using 55451-1-AP (same clone as 55451-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 55451-1-AP (CLEC9A Antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 55451-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human tonsillitis using 55451-1-AP (same clone as 55451-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 55451-1-AP (CLEC9A Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 55451-1-PBS in a different storage buffer formulation.

CLEC9A Polyclonal Antibody for IHC, Indirect ELISA

Cat No. 55451-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, Indirect ELISA

Synonyms

CD370, C-type lectin domain family 9 member A, DNGR1, UNQ9341, UNQ9341/PRO34046

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Product Information

55451-1-PBS targets CLEC9A in IHC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: C-type lectin domain family 9, member A
• Calculated Molecular Weight: 27 kDa
• GenBank Accession Number: NM_207345
• Gene Symbol: CLEC9A
• Gene ID (NCBI): 283420
• RRID: AB_2881338
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q6UXN8
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CLEC9A (C-type lectin domain family 9 member A), also known as DNGR1, CD370, is a type II membrane protein that contains C-type lectin domain. The C-type lectin domain family members share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. Mouse Clec9A is primarily restricted to dendritic cells (DCs) and selectively expressed in mouse CD8+ conventional DCs (cDCs) and plasmacytoid DCs (pDCs), whereas human CLEC9A is also expressed on human DC subtypes. CLEC9A functions as an activating receptor that recruits Syk kinase and can induce the production of proinflammatory cytokines. (PMID: 25553393; PMID: 15476922; PMID: 18669894; PMID: 18408006)