Product Information
22201-1-PBS targets CNGA4 in WB, Indirect ELISA applications and shows reactivity with mouse, rat samples.
| Tested Reactivity | mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag17481 Product name: Recombinant human CNGA4 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 260-394 aa of BC106936 Sequence: TIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLA Predict reactive species |
| Full Name | cyclic nucleotide gated channel alpha 4 |
| Calculated Molecular Weight | 575 aa, 66 kDa |
| Observed Molecular Weight | 47-50 kDa, 65-70 kDa |
| GenBank Accession Number | BC106936 |
| Gene Symbol | CNGA4 |
| Gene ID (NCBI) | 1262 |
| RRID | AB_3669391 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q8IV77 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
CNGA4 (cyclic nucleotide gated channel subunit alpha 4), also known as CNG4. It is expected to be located in cell membrane. Cyclic nucleotide-gated (CNG) channels are crucial for visual and olfactory transductions (PMID: 12432397). Native CNG channels are heterotetramers composed of homologous A and B subunits. Olfactory CNG channels are composed of three types of subunits, CNGA2, CNGA4, and CNGB1b (PMID: 15134638). CNGA4 is a modulatory subunit which contributes to the high cAMP sensitivity of the native olfactory channel. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation of native olfactory neurons to odorants (PMID: 11739959; 11739960). The molecular weight of CNGA4 is 65 kDa, and it can recognize the 48 kDa isoform.
