Product Information
19797-1-AP targets COL4A5 in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | collagen, type IV, alpha 5 |
| Calculated Molecular Weight | 161 kDa |
| GenBank Accession Number | NM_000495 |
| Gene Symbol | COL4A5 |
| Gene ID (NCBI) | 1287 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P29400 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
COL4A5 belongs to the type IV collagen family. Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A5 are the cause of Alport syndrome X-linked (APSX). Deletions covering the N-terminal regions of COL4A5 and COL4A6, which are localized in a head-to-head manner, are the cause of diffuse leiomyomatosis with Alport syndrome (DL-ATS)which also known as esophageal and vulval leiomyomatosis with nephropathy or Alport syndrome and diffuse leiomyomatosis (ATS-DL).
Publications
What published studies show
The COL4A5 Polyclonal antibody (Cat# 19797-1-AP) has 17 citations. Publications appear in journals including Biomaterials, PLoS Genet, FASEB J, Sci Rep, Int J Mol Med, Drug Des Devel Ther, Pharm Biol, Front Pharmacol, Am J Physiol Cell Physiol, Bioorg Chem, J Sex Med, J Diabetes Res, Asian J Androl, Am J Physiol Regul Integr Comp Physiol, J Dev Orig Health Dis, and Andrologia. Research fields span diabetic nephropathy, renal fibrosis, erectile dysfunction, extracellular matrix biology, vascular remodeling, cancer progression, and developmental origins of health and disease.
| Species | Application | Title |
|---|---|---|
Biomaterials A novel bioscaffold with naturally-occurring extracellular matrix promotes hepatocyte survival and vessel patency in mouse models of heterologous transplantation. | ||
Int J Mol Med The Notch pathway mediates the angiotensin II-induced synthesis of extracellular matrix components in podocytes. | ||
Pharm Biol Kirenol alleviates diabetic nephropathy via regulating TGF-β/Smads and the NF-κB signal pathway | ||
Am J Physiol Cell Physiol miR-29c Induction Contributes to Down-Regulation of Vascular Extracellular Matrix Proteins by Glucocorticoids. | ||
Front Pharmacol Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and fibrosis via the NF-κB signaling pathway |
