Product Information
26232-1-PBS targets CPO in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag24059 Product name: Recombinant human CPO protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 21-101 aa of BC112078 Sequence: YDRSLAQHRQEIVDKSVSPWSLETYSYNIYHPMGEIYEWMREISEKYKEVVTQHFLGVTYETHPIYYLKISQPSGNPKKII Predict reactive species |
| Full Name | carboxypeptidase O |
| Calculated Molecular Weight | 374 aa, 43 kDa |
| Observed Molecular Weight | 42 kDa |
| GenBank Accession Number | BC112078 |
| Gene Symbol | CPO |
| Gene ID (NCBI) | 130749 |
| RRID | AB_3742174 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q8IVL8 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
CPO (Carboxypeptidase O) is a member of the M14 family of metallocarboxypeptidases, belonging to the CPA subfamily. It is a GPI-anchored membrane-bound enzyme highly expressed on the brush-border membrane of intestinal epithelial cells. Unlike classical digestive carboxypeptidases such as CPA and CPB, which are secreted as inactive proenzymes, CPO is synthesized as an active enzyme without a prodomain. Its most distinctive biochemical feature is a strong substrate preference for C-terminal acidic amino acids, specifically glutamate and aspartate. This specificity distinguishes CPO from other family members. Its primary physiological role is to complete the digestion of dietary proteins by releasing acidic amino acids for efficient absorption in the small intestine.
