CRNKL1 Recombinant monoclonal antibody, PBS Only

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  IF Staining of MCF-7 using 83914-1-RR (same clone as 83914-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using CRNKL1 antibody (83914-1-RR, Clone: 240697D12 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 83914-1-PBS in a different storage buffer formulation.

CRNKL1 Uni-rAb^® Recombinant Antibody for IF/ICC, ELISA

Cat No. 83914-1-PBS

Clone No.240697D12

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, ELISA

Synonyms

HCRN, Crooked neck like protein 1, Crooked neck homolog, CRN, CLF

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Product Information

83914-1-PBS targets CRNKL1 in IF/ICC, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
• Calculated Molecular Weight: 100 kDa
• GenBank Accession Number: NM_016652
• Gene Symbol: CRNKL1
• Gene ID (NCBI): 51340
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q9BZJ0
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

CRNKL1 (Crooked Neck Pre-MRNA Splicing Factor 1) is involved in pre-mRNA splicing process. As a component of the minor spliceosome, it's involved in the splicing of U12-type introns in pre-mRNAs. It's reported that CRNKL1 is a nuclear retention factor of the HIV-1 unspliced RNA and a selective regulator of cytoplasmic levels of a subset of intron-retaining cellular mRNAs.(PMID: 33468685)