Product Information
16325-1-PBS targets CXCL2 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CXCL2 fusion protein Ag9410 Predict reactive species |
| Full Name | chemokine (C-X-C motif) ligand 2 |
| Calculated Molecular Weight | 107 aa, 11 kDa |
| Observed Molecular Weight | 9 kDa |
| GenBank Accession Number | BC015753 |
| Gene Symbol | CXCL2 |
| Gene ID (NCBI) | 2920 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P19875 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
CXCL2, also known as macrophage inflammatory protein 2-alpha (MIP2-alpha), is a member of CXC chemokine family that binds to CXC chemokine receptor 2 (CXCR2). CXCL2 is mainly produced by macrophages, endothelial cells, epithelial cells and tumor cells. CXCL2 plays important roles in various biological progresses such as angiogenesis, inflammation, immune response and cancer biological behaviors. Under inflammatory conditions in CNS, microglia and astrocytes may secrete CXCL2 as well as other chemokines, which induces chemotaxis and infiltration of circulatory neutrophils. Indeed, previous studies suggest that CXCL2 is involved in Alzheimer disease, multiple sclerosis and brain ischemia.
