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Tested Applications
| Positive FC detected in | U2OS cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Flow Cytometry (FC) | FC : 0.25 ug per 10^6 cells in a 100 µl suspension |
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
98681-1-RR targets Claudin 19 in FC applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | claudin 19 |
| Calculated Molecular Weight | 23 kDa |
| GenBank Accession Number | BC030524 |
| Gene Symbol | CLDN19 |
| Gene ID (NCBI) | 149461 |
| RRID | AB_3746269 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q8N6F1 |
| Storage Buffer | PBS with 0.09% sodium azide, pH 7.3. |
| Storage Conditions | Store at 2 - 8°C. Stable for one year after shipment. |
Background Information
Claudin-19 is a critical transmembrane protein and belongs to the claudin family, which are the primary structural and functional components of tight junctions (TJs) in epithelial and endothelial cell sheets. Mutations in the CLDN19 are primarily associated with Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis (FHHNC) with severe ocular involvement (PMID: 17389678). In breast cancer, Claudin-19 expression is frequently lost or downregulated, which correlates with poor patient prognosis (PMID: 15883201, 37344378).
Protocols
| Product Specific Protocols | |
|---|---|
| FC protocol for Claudin 19 antibody 98681-1-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
