DHX37 Polyclonal antibody, PBS Only

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• DHX37 Polyclonal antibody, PBS Only (29741-1-PBS)

• 

  WB analysis using 29741-1-AP (same clone as 29741-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29741-1-AP (DHX37 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29741-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HEK-293 using 29741-1-AP (same clone as 29741-1-PBS)

  WB result of DHX37 antibody (29741-1-AP; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-DHX37 transfected HEK-293 cells. This data was developed using the same antibody clone with 29741-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

DHX37 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 29741-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

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Product Information

29741-1-PBS targets DHX37 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag29909

  Product name: Recombinant human DHX37 protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 347-718 aa of BC037964

  Sequence: FMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDFTQNPRLFAKPPPVIKVESRQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPPSRARPQEKDDDQKDSVEEMRKFKKSRARAKKARAEVLPQINLDHYSVLPAGEGDEDREAEVDEEEGALDSDLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVE

• Full Name: DEAH (Asp-Glu-Ala-His) box polypeptide 37
• Calculated Molecular Weight: 1157 aa, 130 kDa
• Observed Molecular Weight: 130 kDa
• GenBank Accession Number: BC037964
• Gene Symbol: DHX37
• Gene ID (NCBI): 57647
• RRID: AB_2923602
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q8IY37
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

DHX37, also known as DDX37, KIAA1517. It is an ATP-bound RNA helicase that plays a role in the maturation of small ribosomal subunits in ribosomal biogenesis (PMID:30582406). The presence of DHX37 in early pre-ribosomal particles was monitored by a quality control pathway, and failure to recruit DHX37 resulted in pre-RRNA degradation. DHX37 binds directly to U3 small nucleolar RNA (snoRNA), and the catalytic activity of the helicase is required for dissociation of U3 small nucleolar RNA from the pre-ribosomal complex.In addition, it plays a role in early testicular development (PMID:31287541, PMID:31337883). It may also have an effect on brain development (PubMed:31256877). It is expressed in the fallopian tubes, ovaries, uterus, testes and brain (PMID: 31256877,PMID: 31337883).