DNAH6 Polyclonal antibody

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• DNAH6 Polyclonal antibody (18080-1-AP)

DNAH6 Polyclonal Antibody for IHC, ELISA

Cat No. 18080-1-AP Copied!

Publications (2)

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Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF, ELISA

Synonyms

Ciliary dynein heavy chain 6, DNAH6, Dnahc6, DNHL1, Dynein heavy chain 6, axonemal, HL 2, HL2, KIAA1697

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  IHC staining of mouse brain using 18080-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 18080-1-AP (DNAH6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of human small intestine using 18080-1-AP

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 18080-1-AP (DNAH6 antibody) at dilution of 1:200 (under 40x lens).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of mouse brain using 18080-1-AP

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 18080-1-AP (DNAH6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
• 

  IHC staining of human small intestine using 18080-1-AP

  Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 18080-1-AP (DNAH6 antibody) at dilution of 1:200 (under 10x lens).

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive IHC detected in: human small intestine tissue, mouse brain tissue; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Immunohistochemistry (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

18080-1-AP targets DNAH6 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag12774

  Product name: Recombinant human DNAH6 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-408 aa of BC104884

  Sequence: MTYTEQASKRHYCMRLTCFIRLNDYLIENTMHILTVNAVNSLLNHLTDKLKRTPSADVIQKWITEEKPEVPDKKGTLMVEKQEEDESLIPMFLTELMLTVQSLLFEPSLEDFLDGILGAVNHCQNTVLSVPNLVPDSYFDAFTSPYINNKLEGKTCGTGPSLAAVFEDDKNFHTIISQIKETIQAAFESARIYAATFEKFQIFFKENESLDLQALKLQEPDINFFSEQLEKYHKQHKDAVALRPTRNVGLLLIDTRLLREKLIPSPLRCLEVLNFMLPRQSKKKVDAIIFEAQDAEYKLEFVPTTTTEYVHSLLFLDEIQERIESLEDEGNIVTQMYKLMEQYQVPTPPEDFAVFATMKPSIVAVRNAIDKSVGDRESSIKQFCVHLGSDLEELNNEVNEVKLQAQVS

• Full Name: dynein, axonemal, heavy chain 6
• Calculated Molecular Weight: 475 kDa
• GenBank Accession Number: BC104884
• Gene Symbol: DNAH6
• Gene ID (NCBI): 1768
• RRID: AB_2878493
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9C0G6
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

DNAH6(Dynein heavy chain 6, axonemal) is also named as DNAHC6, DNHL1, HL2, KIAA1697 and belongs to the dynein heavy chain family.Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains(PMID:8812413). It is a force generating protein of respiratory cilia and produces force towards the minus ends of microtubules.This antibody is specific to DNAH6.

Publications

What published studies show

The DNAH6 Polyclonal Antibody (Cat# 18080-1-AP) has 2 citations. One appears in Molecular Psychiatry (IF 10.4, 2021), studying FXR1 regulation of parvalbumin interneurons in schizophrenia-like behaviors using IHC in human and mouse tissues. The other is in eLife (2024), investigating DNAH3 deficiency causing flagellar inner dynein arm loss and male infertility in humans and mice, using WB and IF. The research fields span neuroscience/psychiatry and cilia biology/reproductive medicine.

Automatically generated from the 2 publication citations by Able AI.

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
human,mouse	IHC	Mol Psychiatry; FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors.; Authors - Minjie Shen
human	WB,IF	Elife; DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice; Authors - Xiang Wang