DNER Recombinant monoclonal antibody

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• DNER Recombinant monoclonal antibody (87343-1-RR)

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  WB analysis using 87343-1-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 87343-1-RR (DNER antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

• 

  Affinity of 87343-1-RR

  Biolayer interferometry (BLl) kinetic assays of 87343-1-RR against Human DNER were performed. The affinity constant is 6.66 nM.

DNER Uni-rAb^® Recombinant Antibody for WB, ELISA

Cat No. 87343-1-RR

Clone No.252587F3

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Synonyms

BET, Delta and Notch-like epidermal growth factor-related receptor, UNQ262/PRO299

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Tested Applications

• Positive WB detected in: mouse cerebellum tissue, rat cerebellum tissue, mouse brain tissue, rat brain tissue, mouse spinal cord tissue, rat spinal cord tissue

Recommended dilution

• Western Blot (WB): WB : 1:2000-1:10000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

87343-1-RR targets DNER in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg6559

  Product name: Recombinant human DNER protein

  Source: mammalian cells-derived, V37

  Tag: C-rFc

  Domain: 35-640 aa of NM_139072.4

  Sequence: NPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLY

• Full Name: delta/notch-like EGF repeat containing
• Calculated Molecular Weight: 78 kDa
• Observed Molecular Weight: 140 kDa
• GenBank Accession Number: NM_139072.4
• Gene Symbol: DNER
• Gene ID (NCBI): 92737
• RRID: AB_3745480
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q8NFT8
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Delta and Notch-like epidermal growth factor-related receptor (DNER) is a type I transmembrane protein that is specifically expressed in the developing and mature central nervous system (PMID: 11950833). It contains ten extracellular EGF-like repeats that are closely related to those of the developmentally important receptor Notch and its ligand Delta. DNER functions as a Notch ligand and mediates signaling through neuron-glia interactions (PMID: 15965470).