DR5-Specific Polyclonal antibody, PBS Only

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• DR5-Specific Polyclonal antibody, PBS Only (15497-1-PBS)

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  WB analysis of PC-3 cells using 15497-1-AP (same clone as 15497-1-PBS)

  WB result of 15497-1-AP (TNFRSF10B, DR5 antibody) with PC-3 cell, untreated or treated with tunicamysin. This data was developed using the same antibody clone with 15497-1-PBS in a different storage buffer formulation.

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  WB analysis of HL-60 using 15497-1-AP (same clone as 15497-1-PBS)

  HL-60 cells were subjected to SDS PAGE followed by western blot with 15497-1-AP (TNFRSF10B-Specific antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15497-1-PBS in a different storage buffer formulation.

DR5-Specific Polyclonal Antibody for WB, Indirect ELISA

Cat No. 15497-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

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Product Information

15497-1-PBS targets DR5-Specific in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: tumor necrosis factor receptor superfamily, member 10b
• Calculated Molecular Weight: 48 kDa
• Observed Molecular Weight: 58-60 kDa, 45-50 kDa, 32 kDa
• GenBank Accession Number: NM_003842
• Gene Symbol: DR5
• Gene ID (NCBI): 8795
• RRID: AB_2240702
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O14763
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

TNFRSF10B, also known as CD262, DR5, TRAILR2, TRICK2 and KILLER, is a widely expressed single-pass type I membrane protein belonging to the tumour necrosis factor receptor superfamily (TNFRSF). It is a receptor for TNF-related apoptosis-inducing ligand (TRAIL), which is a member of the tumor necrosis factor (TNF) family of cytokines and induces apoptosis in a wide variety of cells (PMID: 9311998). TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain (DD), through which TNFRSF10B is capable to transmit the apoptotic signal (PMID: 9311998; 20531300). In PDAC cells, especially Panc89 cells, it expresses additionally to the approximately 48 and 40 kDa forms of DR5, a faster migrating variant of DR5 of about 32 kDa(PMID:20354842). The TRAIL receptor 2 (death receptor 5, or DR5) forms receptor dimers in a ligand-dependent manner, and these receptor dimers exist within high molecular weight networks(Dr. Jonathan N. Sachs,2012).