Product Information
26810-1-PBS targets DTWD1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag25170 Product name: Recombinant human DTWD1 protein Source: e coli.-derived, PET30a Tag: 6*His Domain: 1-304 aa of BC032535 Sequence: MSLNPPIFLKRSEENSSKFVETKQSQTTSIASEDPLQNLCLASQEVLQKAQQSGRSKCLKCGGSRMFYCYTCYVPVENVPIEQIPLVKLPLKIDIIKHPNETDGKSTAIHAKLLAPEFVNIYTYPCIPEYEEKDHEVALIFPGPQSISIKDISFHLQKRIQNNVRGKNDDPDKPSFKRKRTEEQEFCDLNDSKCKGTTLKKIIFIDSTWNQTNKIFTDERLQGLLQVELKTRKTCFWRHQKGKPDTFLSTIEAIYYFLVDYHTDILKEKYRGQYDNLLFFYSFMYQLIKNAKCSGDKETGKLTH Predict reactive species |
| Full Name | DTW domain containing 1 |
| Calculated Molecular Weight | 35 kDa |
| Observed Molecular Weight | 35 kDa |
| GenBank Accession Number | BC032535 |
| Gene Symbol | DTWD1 |
| Gene ID (NCBI) | 56986 |
| RRID | AB_3085907 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q8N5C7 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
DTW domain-containing protein 1 (DTWD1), also named as tRNA-uridine aminocarboxypropyltransferase 1, is responsible for 3-(3-amino-3-carboxypropyl)uridine modification at position 20 in the D-loop of certain tRNAs (PMID: 31804502; 37745798). DTWD1 has been identified as a target gene of p53 and functions as a tumor suppressor gene (PMID: 25973305). Dysregulated expression of DTWD1 has been reported in several malignancies, including gastric cancer and colorectal cancer (PMID: 25973305; 31924336).
