Product Information
10172-2-AP targets DUSP14 in ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | DUSP14 fusion protein Ag0228 Predict reactive species |
| Full Name | dual specificity phosphatase 14 |
| Calculated Molecular Weight | 22 kDa |
| GenBank Accession Number | BC004448 |
| Gene Symbol | DUSP14 |
| Gene ID (NCBI) | 11072 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O95147 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulator receptor, such as CD28. CD28 costimulation induces transcription of interleukin-2 and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK and JNK, and the subsequent creation of AP1 transcription factor. DUSP14/ MAP kinase phosphatase-6 (MKP6) is a negative regulator of CD28
