Dymeclin Polyclonal antibody
Dymeclin Polyclonal Antibody for WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
WB, ELISA
Conjugate
Unconjugated
Cat no : 12001-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Positive WB detected in | HEK-293 cells, MCF-7 cells, mouse kidney tissue, mouse pancreas tissue |
Recommended dilution
Application | Dilution |
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Western Blot (WB) | WB : 1:500-1:1000 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
12001-1-AP targets Dymeclin in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Reactivity | human, mouse, rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Dymeclin fusion protein Ag2600 |
Full Name | dymeclin |
Calculated Molecular Weight | 669 aa, 76 kDa |
Observed Molecular Weight | 76-80 kDa |
GenBank Accession Number | BC001252 |
Gene Symbol | Dymeclin |
Gene ID (NCBI) | 54808 |
RRID | AB_2246056 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Human Dymeclin is encoded by DYM gene, defects in which are the cause of Dyggve-Melchior-Clausen syndrome (DMC) and Smith-McCort dysplasia (SMC). DMC is a rare autosomal recessive disorder characterized by short trunk dwarfism, microcephaly and psychomotor retardation, with cutaneous cells containing dilated rough endoplasmic reticulum, enlarged and aberrant vacuoles and numerous vesicles [PubMed: 12491225]. Distinct with features of DMS, SMC is a rare osteochondrodysplasia characterized by short limbs and trunk with barrel-shaped chest [PubMed: 19005420]. Dymeclin is a not a stably anchored transmembrane protein with a transmembrane domain, but it shuttles between Golgi and cytosol, which is necessary for correct organization of Golgi apparatus [PubMed: 18996921].
Protocols
Product Specific Protocols | |
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WB protocol for Dymeclin antibody 12001-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |