Product Information
15949-1-PBS targets DYNC2LI1 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag8584 Product name: Recombinant human DYNC2LI1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-352 aa of BC006969 Sequence: MPSETLWEIAKAEVEKRGINGSEGDGAEIAEKFVFFIGSKNGGKTTIILRCLDRDEPPKPTLALEYTYGRRAKGHNTPKDIAHFWELGGGTSLLDLISIPITGDTLRTFSLVLVLDLSKPNDLWPTMENLLQATKSHVDKVIMKLGKTNAKAVSEMRQKIWNNMPKDHPQDHELIDPFPVPLVIIGSKYDVFQDFESEKRKVICKTLRFVAHYYGASLMFTSKSEALLLKIRGVINQLAFGIDKSKSICVDQNKPLFITAGLDSFGQIGSPPVPENDIGKLHAHSPMELWKKVYEKLFPPKSINTLKDIKDPARDPQYAENEVDEMRIQKDLELEQYKRSSSKSWKQIELDS Predict reactive species |
| Full Name | dynein, cytoplasmic 2, light intermediate chain 1 |
| Calculated Molecular Weight | 352 aa, 40 kDa |
| Observed Molecular Weight | 37-40 kDa, 22 kDa |
| GenBank Accession Number | BC006969 |
| Gene Symbol | DYNC2LI1 |
| Gene ID (NCBI) | 51626 |
| RRID | AB_2093643 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q8TCX1 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
DYNC2LI1 (D2LIC, LIC3) is a member of cytoplasmic dynein 2 complex that is required for retrograde transport. It is ubiquitously expressed with high expression levels in brain, kidney, lung and testes. In mammalian cells, DYNC2LI1 is localized to centrosomal region Mutations in DYNC2LI1 disrupt cilia function and cause various skeletal ciliopathies. There're some isoforms with MW 40 kDa, 38 kDa, 22 kDa and 16 kDa.
