|Positive WB detected in||DU 145 cells, HeLa cells, HepG2 cells|
|Western Blot (WB)||WB : 1:200-1:1000|
|Sample-dependent, check data in validation data gallery|
10071-1-AP targets ELAC2 in WB, IF,ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||ELAC2 fusion protein Ag0105|
|Full Name||elaC homolog 2 (E. coli)|
|Calculated molecular weight||92 kDa|
|Observed molecular weight||92 kDa|
|GenBank accession number||BC004158|
|Gene ID (NCBI)||60528|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Putative prostate cancer susceptibility protein (ELAC2) is encoded by HPC2/ELAC2 gene. HPC2 is a potential prostate cancer predisposition gene playing a role in genetic susceptibility to prostate cancer.It is a zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity and probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.Defects in ELAC2 may be a cause of susceptibility to prostate cancer (PC).
Adult-onset obesity is triggered by impaired mitochondrial gene expression.
How do human cells react to the absence of mitochondrial DNA?
Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs.
Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.
Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria.
GRSF1 regulates RNA processing in mitochondrial RNA granules.