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  • KD/KO Validated

ELAC2 Polyclonal antibody

ELAC2 Polyclonal Antibody for WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF,ELISA

Conjugate

Unconjugated

Cat no : 10071-1-AP

Synonyms

elaC homolog 2 (E. coli), ElaC homolog protein 2, ELAC2, ELC2, HPC2, Ribonuclease Z 2, RNase Z 2, tRNA 3 endonuclease 2, tRNase Z 2



Tested Applications

Positive WB detected inDU 145 cells, HeLa cells, HepG2 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:200-1:1000
Sample-dependent, check data in validation data gallery

Product Information

10071-1-AP targets ELAC2 in WB, IF,ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ELAC2 fusion protein Ag0105
Full Name elaC homolog 2 (E. coli)
Calculated molecular weight 92 kDa
Observed molecular weight 92 kDa
GenBank accession numberBC004158
Gene symbol ELAC2
Gene ID (NCBI) 60528
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Putative prostate cancer susceptibility protein (ELAC2) is encoded by HPC2/ELAC2 gene. HPC2 is a potential prostate cancer predisposition gene playing a role in genetic susceptibility to prostate cancer.It is a zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity and probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.Defects in ELAC2 may be a cause of susceptibility to prostate cancer (PC).

Protocols

Product Specific Protocols
WB protocol for ELAC2 antibody 10071-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Sci Adv

Adult-onset obesity is triggered by impaired mitochondrial gene expression.

Authors - Kara L Perks
humanWB

PLoS One

How do human cells react to the absence of mitochondrial DNA?

Authors - Mineri Rossana R
humanWB,IF

RNA Biol

Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs.

Authors - Brzezniak Lien K LK
  • KD Validated
mouseWB

Cell Rep

Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.

Authors - Oliver Rackham
humanWB

Nat Commun

Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria.

Authors - Zbigniew Pietras
humanIF

Cell Metab

GRSF1 regulates RNA processing in mitochondrial RNA granules.

Authors - Jourdain Alexis A AA