ELN Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 15257-1-AP

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Con: 24 μg/150 μl

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Species specificity:
human, mouse, rat

Positive IP detected in:
human placenta tissue, mouse lung tissue

Positive IHC detected in:
mouse lung tissue

Recommended dilution:
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
elastin

Calculated molecular weight:
68 kDa

Observed molecular weight:
65-78 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ELN

Synonyms
desmosine, elastin, ELN, FLJ38671, FLJ43523, SVAS, Tropoelastin, WBS, WS
Background

Elastic fibers are an abundant and integral part of many extracellular matrices, in which they provide the elastic properties to tissues such as arterial, lung, and skin. Elastic fibers are consisting of an elastin core surrounded by a mantle of fibrillin-rich microfibrils (PMID: 12082143). Elastin is an extremely durable, insoluble biopolymer formed through the lysine-mediated crosslinking of its soluble precursor tropoelastin, which is an approximately 60-70 kDa protein (PMID: 15837523). Deletions and mutations in the elastin gene (ELN) are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa.


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