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Anti-Mouse EPCR/CD201 Rabbit Recombinant Antibody, PBS Only (98248-1-PBS)

Anti-Mouse EPCR/CD201 Rabbit Recombinant Antibody, PBS Only

Name: Anti-Mouse EPCR/CD201 Rabbit Recombinant Antibody, PBS Only, 1mg
Brand: Proteintech
SKU: 98248-1-PBS-1MG

EPCR/CD201 Uni-rAb^® Recombinant Antibody for FC

Cat No. 98248-1-PBS

Clone No. 241853A7

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Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

Synonyms

241853A7, Activated protein C receptor, APC receptor, CD201, Centrocyclin

Formulation: PBS Only

PBS, Azide

PBS Only

Conjugate: Unconjugated

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Filter: AllFCAffinity

FC experiment of bEnd.3 using 98248-1-RR (same clone as 98248-1-PBS)
1x10^6 bEnd.3 cells were surface stained with 0.25 ug Anti-Mouse EPCR/CD201 Rabbit Recombinant Antibody (98248-1-RR, Clone: 241853A7) and PE-Conjugated Goat Anti-Rabbit IgG(H+L) (red), or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L) (blue). Cells were not fixed. This data was developed using the same antibody clone with 98248-1-PBS in a different storage buffer formulation.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy
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1x10^6 bEnd.3 cells were surface stained with 0.25 ug Anti-Mouse EPCR/CD201 Rabbit Recombinant Antibody (98248-1-RR, Clone: 241853A7) and PE-Conjugated Goat Anti-Rabbit IgG(H+L) (red), or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L) (blue). Cells were not fixed. This data was developed using the same antibody clone with 98248-1-PBS in a different storage buffer formulation.
Affinity and Kinetic Characterization of 98248-1-RR
Biolayer interferometry (BLl) kinetic assays of 98248-1-RR against Mouse EPCR/CD201 were performed. The affinity constant is 52.5 pM.
This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Overview

Tested Applications
Product Information

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Product Information

98248-1-PBS targets EPCR/CD201 in FC applications and shows reactivity with mouse samples.

Tested Reactivity	mouse
Host / Isotype	Rabbit / IgG
Class	Recombinant
Type	Antibody
Immunogen	CatNo: Eg1517 Product name: Recombinant Mouse EPCR/CD201 protein (rFc Tag)(HPLC verified) Source: mammalian cells-derived, pHZ-KIsec-C-rFc Tag: C-rFc Domain: 18-214 aa of NM_011171.2 Sequence: LCNSDGSQSLHMLQISYFQDNHHVRHQGNASLGKLLTHTLEGPSQNVTILQLQPWQDPESWERTESGLQIYLTQFESLVKLVYRERKENVFFPLTVSCSLGCELPEEEEEGSEPHVFFDVAVNGSAFVSFRPKTAVWVSGSQEPSKAANFTLKQLNAYNRTRYELQEFLQDTCVEFLENHITTQNMKGSQTGRSYTS Predict reactive species
Full Name	protein C receptor, endothelial
Calculated Molecular Weight	27kDa
GenBank Accession Number	NM_011171.2
Gene Symbol	PROCR
Gene ID (NCBI)	19124
RRID	AB_3745915
Conjugate	Unconjugated
Form	Liquid
Purification Method	Protein A purification
UNIPROT ID	Q64695
Storage Buffer	PBS only, pH 7.3.
Storage Conditions	Store at -80°C.

Background Information

EPCR, also known as CD201, protein C receptor (PROCR), or activated protein C receptor (APC receptor), is a transmembrane glycoprotein. EPCR promotes the activation of protein C, which has anticoagulant and cytoprotective effects. EPCR facilitates the activation of protein C by the thrombin-thrombomodulin complex but also facilitates APC-mediated cytoprotective effects on cells that involve the activation of protease-activated receptors (PAR) 1 and 3(PMID: 27207424).