EPS8L3 Polyclonal antibody, PBS Only

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• EPS8L3 Polyclonal antibody, PBS Only (32571-1-PBS)

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  WB analysis using 32571-1-AP (same clone as 32571-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32571-1-AP (EPS8L3 antibody) at dilution of 1:40000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32571-1-PBS in a different storage buffer formulation.

EPS8L3 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 32571-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

Epidermal growth factor receptor kinase substrate 8-like protein 3, Epidermal growth factor receptor pathway substrate 8-related protein 3, EPS8 Signaling Adaptor L3, EPS8-like protein 3, EPS8R3

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Product Information

32571-1-PBS targets EPS8L3 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag38525

  Product name: Recombinant human EPS8L3 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 408-593 aa of NM_001319952.1

  Sequence: PVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP*

• Full Name: EPS8-like 3
• Calculated Molecular Weight: 67kDa，593aa
• Observed Molecular Weight: 65 kDa
• GenBank Accession Number: NM_001319952.1
• Gene Symbol: EPS8L3
• Gene ID (NCBI): 79574
• RRID: AB_3742659
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q8TE67
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

EPS8L3 (epidermal growth factor receptor kinase substrate 8-like protein 3) is a member of the EPS8 family, encoding a protein associated with the epidermal growth factor receptor (EGFR) signaling pathway. Studies have shown that EPS8L3 is highly expressed in a variety of tumors, such as hepatocellular carcinoma (HCC), pancreatic cancer, and gastric cancer, and is closely associated with tumor proliferation, migration, and invasive ability. It promotes tumor cell proliferation and inhibits apoptosis by activating GSK3β and PI3K/AKT/mTOR signaling pathways. In addition, high expression of EPS8L3 is associated with poor prognosis in tumor patients and may serve as a biomarker for tumor diagnosis and prognostic assessment. Due to its important role in tumors, EPS8L3 is considered a potential therapeutic target, and its inhibition may enhance the efficacy of multi-target kinase inhibitors.