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ERBB2IP Polyclonal antibody

ERBB2IP Polyclonal Antibody for IF, IHC, WB, ELISA

Host / Isotype

Rabbit / IgG







Cat no : 22438-1-AP


Densin 180 like protein, erbb2 interacting protein, ERBB2IP, Erbin, KIAA1225, LAP2, Protein LAP2

Tested Applications

Positive WB detected inHeLa cells, MCF-7 cells
Positive IHC detected inhuman kidney tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inMCF-7 cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:8000
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

22438-1-AP targets ERBB2IP in WB, IHC, IF, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ERBB2IP fusion protein Ag18206
Full Name erbb2 interacting protein
Calculated Molecular Weight 1412 aa, 158 kDa
Observed Molecular Weight 150-180 kDa
GenBank Accession NumberBC115012
Gene Symbol ERBB2IP
Gene ID (NCBI) 55914
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ERBB2IP is a cytoplasmic protein that contains leucine-rich repeats (LRR) and PSD95/Dlg1/zo-1 (PDZ) domain (thus named a LAP protein). ERBB2IP interacts, via its single PDZ domain, specifically with ErbB2, but not with ErbB3, ErbB4, or EGFR. It is colocalized with ErbB2 at the basolateral membranes of epithelial cells. In addition, ERBB2IP also interacts with PSD‐95, Lano and with three p120‐related catenins, eBPAG1 and the β4 subunit of the α6β4 integrin, two major components of hemidesmosomes. The molecular weight of ERBB2IP was predicted 150~180 kDa by Western Blot.(PMID: 25288731,PMID: 24252174,PMID: 19289088)


Product Specific Protocols
WB protocol for ERBB2IP antibody 22438-1-APDownload protocol
IHC protocol for ERBB2IP antibody 22438-1-APDownload protocol
IF protocol for ERBB2IP antibody 22438-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



J Exp Med

ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans.

Authors - J J Lyons

Oncol Lett

Reduced IκBα promotes hepatocellular carcinoma cell proliferation and migration via regulation of NF-κB/Erbin axis.

Authors - Ye Tan

Mol Cancer Res

Desmoglein 1 regulates invadopodia by suppressing EGFR/Erk signaling in an Erbin-dependent manner.

Authors - Alejandra Valenzuela-Iglesias