ESR2 Beta-3 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 55441-1-AP

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Freight/Packing

Con: 43 μg/150 μl

Choose size:

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Species specificity:
human

Positive IHC detected in:
human cervix tissue, human breast cancer tissue, human cervix tissue, human endometrial cancer tissue

Recommended dilution:
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
estrogen receptor 2 (ER beta)

Calculated molecular weight:
58 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ESR2

Synonyms
ER BETA, Erb, ESR BETA, ESR2, ESRB, ESTRB, estrogen receptor 2 (ER beta), Estrogen receptor beta, NR3A2
Background

Estrogen receptor-beta (ESR2) is a member of the superfamily of nuclear receptors, which can transduce extracellular signals into transcriptional responses. It binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual


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