Product Information
33574-1-PBS targets ESS2/DGCR14 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag37915 Product name: Recombinant human ESS2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-250 aa of NM_022719 Sequence: METPGASASSLLLPAASRPPRKREAGEAGAATSKQRVLDEEEYIEGLQTVIQRDFFPDVEKLQAQKEYLEAEENGDLERMRQIAIKFGSALGKMSREPPPPYVTPATFETPEVHAGTGVVGNKPRPRGRGLEDGEAGEEEEKEPLPSLDVFLSRYTSEDNASFQEIMEVAKERSRARHAWLYQAEEEFEKRQKDNLELPSAEHQAIESSQASVETWKYKAKNSLMYYPEGVPDEEQLFKKPRQVVHKNTR Predict reactive species |
| Full Name | DiGeorge syndrome critical region gene 14 |
| Calculated Molecular Weight | 476aa, 53 kDa |
| Observed Molecular Weight | 50-60 kDa |
| GenBank Accession Number | NM_022719 |
| Gene Symbol | DGCR14 |
| Gene ID (NCBI) | 8220 |
| RRID | AB_3743016 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q96DF8 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
ESS2 splicing factor homolog (ESS2), also named DiGeorge-syndrome critical region 14 (DGCR14), acts as a transcriptional co-activator for retinoic acid receptor-related orphan nuclear receptor gamma/gamma-t (Rorγ/γt). Ess2 is a nuclear protein with a coiled-coil domain [6] that is conserved from yeasts to humans. ESS2 is a member of the deletion gene cluster in the 22q11.2 deletion syndrome (22q11.2DS, also known as DiGeorge syndrome or CATCH 22 syndrome). The syndrome is characterized by varying defects of the heart, thymus and parathyroid glands.
