|Positive WB detected in||HeLa cells, HepG2 cells, MCF-7 cells, PC-3 cells|
|Positive IF detected in||PC-3 cells|
|Western Blot (WB)||WB : 1:1000-1:6000|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
13011-1-AP targets ETV5 in WB, IF, CoIP, ChIP,ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||ETV5 fusion protein Ag3708|
|Full Name||ets variant 5|
|Calculated molecular weight||510 aa, 58 kDa|
|Observed molecular weight||58 kDa|
|GenBank accession number||BC007333|
|Gene ID (NCBI)||2119|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
ETS variant gene 5(ETV5) belongs to the ETS oncogene family that shares a conserved peptide, ETS domain, which mediates sequence-specific DNA binding. ETV5 is a transcription factor and is required for spermatogonial stem cell self-renewal. ETV5 can be negatively regulated by COP1, a tumor suppressor. Also it has a role in branching morphogenesis in the developing kidney
Mol Cell Endocrinol
ETV5 regulates GOAT/ghrelin system in an mTORC1-dependent manner.
FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling.
Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors.
Biological and RNA regulatory function of MOV10 in mammalian germ cells.
Endocr Relat Cancer
Interaction of BRAF-induced ETS factors with mutant TERT promoter in papillary thyroid cancer.
J Biol Chem
ETS variant transcription factor 5 and c-Myc cooperate in derepressing the human telomerase gene promoter via composite Ets/E-box motifs.