Product Information
29366-1-PBS targets FAM83G in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag28925 Product name: Recombinant human FAM83G protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 574-823 aa of NM_001039999 Sequence: NGLDGVEEEDDDDYVTLSDQDSHSGSSGRGPGPRRPSVASSVSEEYFEVREHSVPLRRRHSEQVANGPTPPPRRQLSAPHITRGTFVGPQGGSPWAQSRGREEADALKRMQAQRSTDKEAQGQQFHHHRVPASGTRDKDGFPGPPRYRSAADSVQSSTRNAGPAMAGPHHWQAKGGQVPRLLPDPGSPRLAQNARPMTDGRATEEHPSPFGIPYSKLSQSKHLKARTGGSQWASSDSKRRAQAPRDRKDP Predict reactive species |
| Full Name | family with sequence similarity 83, member G |
| Calculated Molecular Weight | 91 kDa |
| Observed Molecular Weight | 100 kDa |
| GenBank Accession Number | NM_001039999 |
| Gene Symbol | FAM83G |
| Gene ID (NCBI) | 644815 |
| RRID | AB_3669686 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | A6ND36 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
FAM83G is a member of the FAM83 protein family, which consists of eight members characterized by sharing a conserved N-terminal domain named DUF1669. This domain is homologous to the phospholipase D catalytic domain but lacks essential catalytic histidine residues, suggesting it is unlikely to have phospholipase activity. FAM83G, in particular, has a consensus motif for serine/threonine protein kinase D1/protein kinase C mu (PKD1/PKCμ) phosphorylation at serine residue 356 (S356), which suggests it may have a unique physiological function among the FAM83 protein family members. Furthermore, FAM83G has been identified as a novel inducer of apoptosis, with its phosphorylation at S356 modulating heat shock protein 27 (HSP27) phosphorylation and apoptosis regulation.
