• Featured Product
  • KD/KO Validated

FDPS Polyclonal antibody

FDPS Polyclonal Antibody for WB, IP, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, IHC, ELISA

Conjugate

Unconjugated

Cat no : 16129-1-AP

Synonyms

FDPS, FPP synthase, FPPS, FPS, KIAA1293



Tested Applications

Positive WB detected inHepG2 cells, A431 cells, human cerebellum tissue, rat liver tissue
Positive IP detected inmouse liver tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:5000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

16129-1-AP targets FDPS in WB, IP, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen FDPS fusion protein Ag9115
Full Name farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
Calculated Molecular Weight 419 aa, 48 kDa
Observed Molecular Weight 39-41 kDa
GenBank Accession NumberBC010004
Gene Symbol FDPS
Gene ID (NCBI) 2224
RRIDAB_2104749
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

FPPS (also known as FDPS) is a key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. The expression of FPPS was elevated in prostate tumor cell lines, indicating its potential role in prostate cancer progression.

Protocols

Product Specific Protocols
WB protocol for FDPS antibody 16129-1-APDownload protocol
IP protocol for FDPS antibody 16129-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Cell Metab

Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism

Authors - Xin Yang
  • KD Validated
mouseWB, IHC

Cardiovasc Res

Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.

Authors - Jian Yang
humanWB,IHC

EBioMedicine

Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling.

Authors - Parthasarathy Seshacharyulu
WB

J Biol Chem

Does Viperin Function as a Radical S-adenosyl-L-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity?

Authors - Caitlyn Makins
mouseWB

Front Pharmacol

Transcriptomic Analysis Reveals the Protective Effects of Empagliflozin on Lipid Metabolism in Nonalcoholic Fatty Liver Disease.

Authors - Yuting Ma
mouseWB

Int J Biochem Cell Biol

Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo.

Authors - Yang Jian J