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Fibrinogen Beta Chain Polyclonal antibody
Fibrinogen Beta Chain Polyclonal Antibody for IHC, WB, ELISA
Cat no : 16747-1-AP
|Positive WB detected in||mouse heart tissue, mouse kidney tissue, mouse brain tissue, mouse liver tissue|
|Positive IHC detected in||human kidney tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:1000-1:8000|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
The immunogen of 16747-1-AP is Fibrinogen Beta Chain Fusion Protein expressed in E. coli.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, Plasmodium falciparum, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Fibrinogen Beta Chain fusion protein Ag10169|
|Full Name||fibrinogen beta chain|
|Calculated molecular weight||491 aa, 56 kDa|
|Observed molecular weight||50 kDa|
|GenBank accession number||BC107766|
|Gene ID (NCBI)||2244|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.1% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA), beta (FGB), gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing, and neoplasia (PMID: 16102057). FGB is the beta chain of fibrinogen. During conversion of fibrinogen to fibrin, fibrinopeptide B is cleaved from FGB by thrombin. Mutations in the gene of FGB lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
Int J Lab Hematol
Clinical application of a new latex photometric immunoassay reagent, LPIA-GENESIS D-dimer, and its performance in patient-derived plasma samples.
The malaria parasite Plasmodium falciparum in red blood cells selectively takes up serum proteins that affect host pathogenicity.
Fibrinogen Chains Intrinsic to the Brain.
Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury.