FGFBP1 Polyclonal antibody

• Featured Product
• KD/KO Validated

FGFBP1 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Publications

5

Cat no : 25006-1-AP

Synonyms

17 kDa HBGF binding protein, FGF binding protein 1, FGF BP, FGF BP1, FGFBP, FGFBP 1, FGFBP1, HBP17, Heparin-binding protein 17

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Validation Data Gallery

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  IHC staining of human skin cancer using 25006-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 25006-1-AP (FGFBP1 antibody) at dilution of 1:200 (under 10x lens).

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  IHC staining of human skin cancer using 25006-1-AP

  Immunohistochemical analysis of paraffin-embedded human skin cancer tissue slide using 25006-1-AP (FGFBP1 antibody) at dilution of 1:200 (under 40x lens).

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Tested Applications

• Positive IHC detected in: human skin cancer tissue; Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

• Immunohistochemistry (IHC): IHC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• KD/KO: See 1 publications below
• WB: See 5 publications below
• IHC: See 3 publications below

Product Information

The immunogen of 25006-1-AP is FGFBP1 Fusion Protein expressed in E. coli.

• Tested Reactivity: human, mouse
• Cited Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: FGFBP1 fusion protein Ag6357
• Full Name: fibroblast growth factor binding protein 1
• Calculated Molecular Weight: 26 kDa
• GenBank Accession Number: BC003628
• Gene Symbol: FGFBP1
• Gene ID (NCBI): 9982
• RRID: AB_2879843
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

FGFBP1, also named as HBP17, is prominent for its role as the chaperone for fibroblast growth factor-2 (FGF-2), which plays a crucial role in angiogenesis as well as promoting tumor growth. HBp17/FGFBP-1 has been proposed as a candidate biomarker for a number of cancers since it is frequently found to be elevated in many cancer types including in the tissue and cell lines of oral squamous cell carcinomas (OSCC).

Publications

Species	Application	Title
human	WB,IHC	Front Immunol; FGFBP1 as a potential biomarker predicting bacillus Calmette-Guérin response in bladder cancer; Authors - Fei Li
mouse	WB,IHC	Am J Cancer Res; Type-2 11β-hydroxysteroid dehydrogenase promotes the metastasis of colorectal cancer via the Fgfbp1-AKT pathway.; Authors - Jin Chen ; KD Validated
human	WB,IHC	Transl Oncol; Identification of metastasis-associated exoDEPs in colorectal cancer using label-free proteomics.; Authors - Xinlu Liu
human	WB	Pharm Biol; Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro; Authors - Yang Yang
human,mouse	WB	Cell Death Dis; Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop; Authors - Yingying Shen