FGFR4 Polyclonal antibody, PBS Only

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• FGFR4 Polyclonal antibody, PBS Only (11098-1-PBS)

• 

  WB analysis using 11098-1-AP (same clone as 11098-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 11098-1-AP (FGFR4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11098-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 11098-1-AP (same clone as 11098-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 11098-1-AP (FGFR4 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11098-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 11098-1-AP (same clone as 11098-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 11098-1-AP (FGFR4 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11098-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 11098-1-AP (same clone as 11098-1-PBS)

  Immunofluorescent analysis of (-20℃ Ethanol) fixed HepG2 cells using 11098-1-AP (FGFR4 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 11098-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

FGFR4 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Cat No. 11098-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IF/ICC, Indirect ELISA

Synonyms

CD334, EC:2.7.10.1, FGFR 4, FGFR-4, JTK2

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Product Information

11098-1-PBS targets FGFR4 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag1573

  Product name: Recombinant human FGFR4 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 503-802 aa of BC011847

  Sequence: KMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT

• Full Name: fibroblast growth factor receptor 4
• Calculated Molecular Weight: 88 kDa
• Observed Molecular Weight: 95, 100-110 kDa
• GenBank Accession Number: BC011847
• Gene Symbol: FGFR4
• Gene ID (NCBI): 2264
• RRID: AB_2103657
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: P22455
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand-binding domains (PMID: 32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID: 20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression(PMID: 10336501).