Anti-Human FGFR4 Rabbit Recombinant Antibody, PBS Only

FGFR4 {ptg:Brand} Recombinant Antibody for FC
Cat No. 98383-2-PBS
Clone No.242713H4

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

CD334, EC:2.7.10.1, FGFR 4, FGFR-4, JTK2

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

98383-2-PBS targets FGFR4 in FC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein Predict reactive species
Full Name fibroblast growth factor receptor 4
Calculated Molecular Weight 88 kDa
GenBank Accession NumberBC011847
Gene Symbol FGFR4
Gene ID (NCBI) 2264
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP22455
Storage Buffer PBS only , pH 7.3
Storage ConditionsStore at -80°C.

Background Information

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains (PMID:32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID:20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression (PMID:10336501).

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